APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase.

Cell Death Dis · 2013 · PMC3920950 · PMID 24157875

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did not reach statistical significanceno p-value reported

TrxR1-siRNA-2 was more efficient than TrxR1-siRNA-1 in protecting cells against APR-246, but this difference did not reach statistical significance.

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