Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.

J Antimicrob Chemother · 2014 · PMC3922157 · PMID 24235095

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did not reach statistical significanceno p-value reported

Expression of TbAQP2 in B48 increased uptake of 50 nM pentamidine 27.7-fold ( P < 0.02; Figure 5 a) to a level that appeared somewhat higher than that in TbAT1 -KO, although that difference did not reach statistical significance.

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