Sensitization of U937 leukemia cells to doxorubicin by the MG132 proteasome inhibitor induces an increase in apoptosis by suppressing NF-kappa B and mitochondrial membrane potential loss.

Cancer Cell Int · 2014 · PMC3927225 · PMID 24495648

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a significant trendno p-value reported

With the combination of both drugs, we observed a significant trend toward upregulation of proapoptotic genes DIABLO , NOXA , BAX , FAS , and DR4 , and downregulation of the antiapoptotic genes BCL-XL and SURVIVIN .

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