Organophosphate-induced changes in the PKA regulatory function of Swiss Cheese/NTE lead to behavioral deficits and neurodegeneration.

PLoS One · 2014 · PMC3928115 · PMID 24558370

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

not quite statistically significantp = 0.054so close (0.05 < p ≤ 0.1)

In this case, the phenotype would be caused by increased PKA-C3 inhibition due to the excess of binding-competent SWS (we previously showed that increased SWS expression reduced PKA activity though the effect was not quite statistically significant with a value of p = 0.054; [24] ).

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highly significantno p-value reported

Comparing the treated heterozygous sws 1 flies to treated controls ( elav >lacZ) showed a highly significant difference with a p-value of 0.0008.

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did not reach statistical significanceno p-value reported

Performing quantitative PCR we found a decrease in PKA-C3 mRNA levels in the heterozygous knockdown however this did not reach statistical significance.

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