In the multivariate analysis the variables found to have a negative impact on NRM were advanced disease status at transplantation (HR 2.2, P : 0.01) and development of grade 2–4 aGVHD (HR: 2.5, P : 0.01), whereas low median CsA blood levels on the third week after transplantation showed a trend as additional independent risk factor for NRM ( P : 0.06).
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Impact of cyclosporine levels on the development of acute graft versus host disease after reduced intensity conditioning allogeneic stem cell transplantation.
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