Decrease of UPR- and ERAD-related proteins in Pichia pastoris during methanol-induced secretory insulin precursor production in controlled fed-batch cultures.

oxidative stress response, amino acid metabolism) did not show a clear trend concerning their changes in abundance while ribosomal proteins revealed a slight decrease in abundance presumably as a result of the lower growth rate in the methanol fed-batch phase (Figure 1 , Additional file 1 : Figure S1 and Additional file 1 : Table S2).

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