The quinoxaline di-N-oxide DCQ blocks breast cancer metastasis in vitro and in vivo by targeting the hypoxia inducible factor-1 pathway.

In line with the obtained results, 5 μM DCQ under hypoxia significantly reduced the viability of MCF-7 and MDA-MB-231 (Additional file 1 : Figure S2); however, the cytotoxic activity of TPZ did not reach statistical significance even at relatively high concentrations (20 μM) under both normoxic and hypoxic conditions (Additional file 1 : Figure S2).

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