Barely Significant
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Subacute administration of crude khat (Catha edulis F.) extract induces mild to moderate nephrotoxicity in rats.

BMC Complement Altern Med · 2014 · PMC3933508 · PMID 24555719

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Compared to GEN rats, GK100 and GK200 tended to have a reduced renal activity of SOD and catalase that failed to reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.