Interestingly, we found that higher mRNA expression of IL-1ß in human adipose tissue was associated with higher mRNA levels of MAP3K8, although this difference did not reach statistical significance, p = 0.063 ( Fig. 2a ).
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MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice.
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0.0630
0.0630