Clonal expansion during Staphylococcus aureus infection dynamics reveals the effect of antibiotic intervention.

In order to define an appropriate drug concentration, tetracycline response experiments were conducted, whereupon embryos infected with 1500 CFU SH1000 EryR (GMSA015) were immersed in sterile E3 medium containing a range of antibiotic doses for the duration of the experiment ( Figure S3A ).While 50 μg/ml tetracycline produced a highly significant, curative response ( p = 0.0003), 10 μg/ml tetracycline showed a trend towards curing ( p = 0.0753) and 5 μg/ml was entirely sub-curative ( p = 0.2181).

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