Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan.

PLoS One · 2014 · PMC3938562 · PMID 24587167

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Pretreatment with the second σ 1 preferring antagonist BD1047 showed a trend toward the attenuation of the antidepressant-like effects of dextromethorphan (30 mg/kg), with the results of 10 mg/kg pretreatment with BD1047 illustrated in Figure 2B .

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