Aging promotes pro-fibrotic matrix production and increases fibrocyte recruitment during acute lung injury.

As further evidence in support of these findings, we also determined that fibrocytes cultured on an ECM derived from Thy-1(+) lung fibroblasts showed a trend toward an increase in cleaved caspase 3 protein expression as compared to other conditions regardless of TGFβ1 treatment ( Figure 7C ). 4.

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