showed a trendp = 0.0593
Calcium accumulation in channelled constructs showed a trend towards a significant increase, as compared to solid constructs, at 4 weeks post-implantation (4.37±0.61 vs. 3.27±0.33%ww, p = 0.0593), with this difference becoming significant at 8 weeks post-implantation (7.97±1.15 vs. 5.12±0.53%ww, p <0.0001).