showed a trendP = 0.01
Additionally, the levels of IGF-1 showed a trend toward a decrease with advancingtumor stage, determined by the American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) staging ( ρ = −0.218, P = 0.01) and Okuda ( ρ = −0.273, P = 0.001).