Calcium-induced MPTP opening in DJ-1 WT and DJ-1 KO mice It was not possible to examine MPTP opening in primary isolated cardiomyocytes, as there was a strong trend to decreased mitochondrial membrane potential in DJ-1 KO hearts ( Supplementary Figure S2 ), thereby precluding the use of the tetramethyl rhodamine methyl ester (TMRM)-based MPTP opening model.
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DJ-1 protects against cell death following acute cardiac ischemia-reperfusion injury.
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