Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models.

In contrast, the SC preconditioning of SW48 cells induced the development of multiple metastases at the lymph nodes, lung and peritoneum in the SC+ORT group, a highly significant difference for each metastatic site ( P <0.05, Table 2 ).

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In the SW48 tumour model, we observed a trend towards a higher number of tumour buds and single cells in the SC+ORT group but this did not reach statistical significance.

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