Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder.

Schizophrenia showed a trend toward a non-random distribution ( χ 2 =2.764, P <0.01, Fisher's P =0.08), although bipolar disorder did not ( Figures 2a and b , x axis; Supplementary Table 1 ).

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As found in other cohorts, substantial individual differences in expression level were identified suggesting that there may be significant heterogeneity within each diagnostic category. 14 Use of clustering to identify subgroups We performed three recursive two-step clustering analyses using our 8 inflammatory-related genes ( SERPINA3 , IL1B , IL1RL1 , IL6 , IL8 , IL18 , TNF and PTGS2 ) as well as previously published data on 11 mRNAs

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