Par6 is an essential mediator of apoptotic response to transforming growth factor beta in NMuMG immortalized mammary cells.

Cancer Cell Int · 2014 · PMC3945291 · PMID 24581220

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In contrast, in response to TGFβ treatment, Par6/S345A cells showed a trend toward increased p65/RelA S536 phosphorylation, while phosphorylation at the same site remained relatively unchanged in β4 null cells at both time points (Figure 9 B,D).

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