Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia.

PLoS One · 2014 · PMC3946485 · PMID 24608088

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Patients who had both types of FLT3 mutations showed a trend towards worse OS compared to patients with single FLT3 -ITD mutation status (HR: 1.1, 95% CI: 0.4–3.3) ( Figure 1A ). 443 of 672 patients achieved a CR.

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