Use of macrolides in mother and child and risk of infantile hypertrophic pyloric stenosis: nationwide cohort study.

Additional sensitivity analyses To assess whether the borderline significant association between maternal use of macrolides during gestational weeks 28 to birth and IHPS was driven by postnatal use of macrolides, we performed analyses with censoring at any postnatal use of macrolides, yielding a rate ratio of 1.54 (95% confidence interval 0.77 to 3.09).

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In line with our results, a previous smaller study reported a twofold to threefold increased risk of IHPS associated with maternal macrolide use after birth, although the results did not reach statistical significance. 21 For maternal use during days 14 to 120 we did not find evidence of an association with IHPS.

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