Hypoxia promotes migration and induces CXCR4 expression via HIF-1α activation in human osteosarcoma.

Thirty-eight of the 46 samples (83%) that expressed CXCR4 also expressed HIF-1α ( Figure 4B ), and this association was highly significant (p<0.001, Spearman's rank correlation).

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Interestingly, Knowles HJ demonstrated that OS cells showed a trend toward increased hypoxic migration and responded to HIF-siRNA, with targeted inhibition of HIF-2α resulting in increased cell migration under hypoxia [35] .

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