Proton pump inhibition increases rapid eye movement sleep in the rat.

Further, we observed in the hourly analysis that percent REM sleep showed a trend towards an increase in the high dose group at every hour starting from the 3rd to 6th hour time period compared to the baseline, vehicle, and low dose groups, with a statistically significant increase only at the 4th hour ( P < 0.05; F (3,27) = 3.88) (data not shown).

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It has been reported earlier that mild hypercapnia significantly increased NREM sleep with an increasing trend of REM sleep frequency [ 16 – 18 ].

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