Effect of treatment with interferon beta-1a on changes in voxel-wise magnetization transfer ratio in normal appearing brain tissue and lesions of patients with relapsing-remitting multiple sclerosis: a 24-week, controlled pilot study.

Change in Volume of NABT with VW-MTR Following 12 and 24 Weeks of Treatment with SC IFN β-1a The median [range] difference in NABT volume with increase in VW-MTR from baseline to 24 weeks between patients and HCs approached significance (1206 [0–15278] and 342 [0–951] mm 3 , respectively; p = 0.061, unadjusted) ( Figure 2A and Table 3 ).

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For NABT, increases in VW-MTR in patients were much greater than those observed in HCs, but the variation was such that the difference fell short of significance at 24 weeks.

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