Anti-epidermal growth factor receptor monoclonal antibody-based therapy for metastatic colorectal cancer: a meta-analysis of the effect of PIK3CA mutations in KRAS wild-type patients.

Arch Med Sci · 2014 · PMC3953972 · PMID 24701207

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failed to reach statistical significanceno p-value reported

The previous meta-analysis suggested that PIK3CA exon 20 mutations might be a potential biomarker for resistance to anti-EGFR MoAbs in KRAS wild-type mCRC [ 38 ], even though it failed to reach statistical significance, most likely due to the small sample size.

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