Protease-activated receptor-2 activation contributes to house dust mite-induced IgE responses in mice.

Although this will need further investigation, possible cooperative TLR-4 and PAR-2 activation, could explain why we observe an increase of pro-inflammatory cytokines in the Par-2 deficient mice after HDM exposure, independent of whether the extract contained high or low serine protease activity, although this failed to reach significance.

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Next, we investigated the HDM-specific IgG1 response, which showed that both HDM extracts induced significant levels of HDM-specific IgG1 in both Wt and Par-2 deficient mice ( Figure 2E–F ), although this induction failed to reach statistical significance in Citeq HDM-treated Par-2 deficient mice ( Figure 2F ).

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