ST2 deficiency does not impair type 2 immune responses during chronic filarial infection but leads to an increased microfilaremia due to an impaired splenic microfilarial clearance.

Increased release of the measured cytokines of splenocytes from ST2-ko mice during the late phase of chronic infection (100 dpi) did not reach statistical significance compared to LsAg stimulated spleen cells of WT controls ( Fig.

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