Among 45 variants in 11 genes, HDM2 promoter polymorphisms emerge as new candidate biomarker associated with radiation toxicity.

3 Biotech · 2014 · PMC3964253 · PMID 28324443

Europe PMC DOI

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a clear trendno p-value reported

Although variations were present, patients who developed severe fibrosis (G3–4) showed a clear trend to harbor higher number of risk alleles.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.