Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.

Interestingly, we observed a modest negative correlation (r = −0.3287) of endogenous TCF21 and miR-224 expression levels in HCASMC treated with PDGF-BB, although this result did not reach statistical significance ( Fig. 6A ).

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These studies employing RNA from circulating leukocytes show highly significant ASE at the TCF21 gene, and consistent allelic expression divergence suggests that rs12190287 is the causal SNP.

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