Comment on: Valette et al. Melanocortin-4 receptor mutations and polymorphisms do not affect weight loss after bariatric surgery. PLOS ONE 2012; 7(11):E48221.

PLoS One · 2014 · PMC3970954 · PMID 24686325

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hedged sentence

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closest p

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boldest claim

The sentences

nominally significantno p-value reported

The fact that the authors only demonstrated a nominally significant association between the more prevalent MC4R genotype group (22 carriers of the −178 A/C polymorphism) and surgical outcomes argues for an overall lack of statistical power in the study.

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