Gain of ALK gene copy number may predict lack of benefit from anti-EGFR treatment in patients with advanced colorectal cancer and RAS-RAF-PI3KCA wild-type status.

PLoS One · 2014 · PMC3972159 · PMID 24691006

Europe PMC DOI

hedged sentence

0.8850

closest p · 17.7× alpha

0.8850

boldest claim

The sentences

did not reach statistical significancep = 0.885not close (p > 0.1)

OS was slightly worsened in patients with increased ALK gene copy number, although this difference did not reach statistical significance (15.6 vs. 18.5 months; HR = 1.181, 95% CI, 0.623–1.738; p = 0.885; Figure 4 ).

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