We found that % area of collagen fibrils within the renal interstitium was reduced in pcy/pcy mice lacking periostin compared to pcy/pcy:Postn +/+ mice; however, this difference did not reach statistical significance (P = 0.06) ( Fig. 7 ).
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Periostin promotes renal cyst growth and interstitial fibrosis in polycystic kidney disease.
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