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Prediction and prevention of the first psychotic episode: new directions and opportunities.

Ther Clin Risk Manag · 2014 · PMC3974689 · PMID 24729711

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66 At the end of the treatment phase, 16% of the UHR individuals treated with olanzapine and 38% of the placebo group converted to psychosis, but the difference between transition rates did not reach statistical significance. 66 Moreover, increased conversion rates and subthreshold symptom exacerbation were observed in the olanzapine group after 1 year of drug withdrawal, suggesting that this antipsychotic therapy may delay, but not prevent, the appearance of FEP. 66 In respect to the possibility that atypical antipsyc

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