Even a small change in proliferation may be significant over time and it is interesting that the changes preferentially occurred in CD86 − cells.
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Stem and progenitor cell subsets are affected by JAK2 signaling and can be monitored by flow cytometry.
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The sentences
While the results would be consistent with expansion of CD86 - HSC in JAK2 transgenics, they did not reach statistical significance and the same was true for some multipotent progenitor subsets ( Figure 6B , Trumpp method, middle panel; Morrison method, far right panel).