To recapitulate, the data show two things: first, LTD is manifested differently in different stripes; and secondly, some of the molecules implicated in the LTD signaling pathways also show expression patterns restricted to stripes, ranging from convincing (e.g., mGluR1b, EAAT4, PLCβ3, PLCβ3/4, GABA B R2) to intriguing (e.g., nNOS, CRF), to being of marginal significance at best (e.g., IP 3 R; IGF-1; PKCδ: Table 1 ).
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Purkinje cell stripes and long-term depression at the parallel fiber-Purkinje cell synapse.
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