Cholesterol accumulation caused by low density lipoprotein receptor deficiency or a cholesterol-rich diet results in ectopic bone formation during experimental osteoarthritis.

In contrast, the combination of LDLr −/− and a cholesterol-rich diet only showed a trend towards an increased total size of enthesophytes compared to WT mice on a normal diet; however, values did not reach significance (Figure 4 B and C).

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