The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer: a retrospective study including patients from the randomised Stockholm tamoxifen trials.

Breast Cancer Res · 2013 · PMC3978839 · PMID 24131622

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borderline significantno p-value reported

In addition, cytoplasmic p4EBP1 (Figure 5 a) was shown borderline significant in relation to a poor prognosis in this patient group .

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reached borderline significanceno p-value reported

In the Stockholm 2 cohort, the correlation between S6K2 and/or 4EBP1 and high S-phase fraction reached borderline significance.

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borderline significanceno p-value reported

The combined variable S6K2 and/or 4EBP1 mRNA was confirmed as a significant prognostic factor, related to poor outcome, in the van de Vijver and Karolinska cohorts, and a borderline significance was seen in the Uppsala cohort (Figure 3 b,c,d).

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