Repeated autologous intraarticular blood injections as an animal model for joint pain in haemophilic arthropathy.

Here, outward rotation (angle between paws) was unaltered, while stride length (distance from left to right paw print) tended to decrease towards later observation time points, but did not reach statistical significance (F(32,101) = 1.256; P = 0.113 and F(32,101) = 1.183; P = 0.261, respectively, Table 1 , data for contralateral side not shown).

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Moreover, while acute injury with haemarthrosis in mice deficient for factor VIII immediately leads to a transient loss of locomotor performance as assessed using a rotarod, those animals that, in fact, develop synovitis after three injuries show a delayed, but highly significant alteration of their locomotor behaviour which may be influenced by both pain and joint destruction [ 27 ].

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