Attenuation of pathogenic immune responses during infection with human and simian immunodeficiency virus (HIV/SIV) by the tetracycline derivative minocycline.

In contrast to the lack of an effect on type I IFN responses in the SIV-infected spleens, minocycline treatment showed a trend towards reduced SIV RNA levels in spleen compared to infected, untreated animals, reducing viral loads by approximately 50%.

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