The role of therapeutic leukapheresis in hyperleukocytotic AML.

The risk score showed a highly significant univariate impact when applied into a logistic regression model on ED d7 , p = 0.002; Odds Ratio (OR): 2.7; 95% CI: 1.5–5.0).

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Complications that occurred in the first 7 days after start of treatment included mostly bleeding and thromboembolic events and were not significantly different between the two patient cohorts, although there was a slight trend towards a higher thromboembolic risk in patients that underwent leukapheresis.

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The frequency of major thromboembolic complications showed a trend to occur more often in patients with leukapheresis.

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