Evidence for aberrant astrocyte hemichannel activity in Juvenile Neuronal Ceroid Lipofuscinosis (JNCL).

We confirmed these observations in the HPC of CLN3 Δex7/8 mice at postnatal day 60, as revealed by a trend towards elevated glutamate coincident with significantly reduced GABA levels compared to WT animals, although the former did not reach statistical significance ( Figure 9D ).

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