Thereby, although the results obtained suggest that allele C in rs6854854 has a protective role against melanoma (p- value = 4×10 −5 ), with an OR of 0.541 (95% CI 0.371–0.791; p- value = 0.0013), after genotyping 464 MM patients and 400 disease-free controls, the ANXA5 rs6854854 SNP did not reach statistical significance in validation Phase II.
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