The impact of pegylated interferon and ribavirin combination treatment on lipid metabolism and insulin resistance in chronic hepatitis C patients.

In a recent study of 412 Italian patients, SVR was associated with HCV genotypes 2 and 3 and younger age, but baseline HOMA-IR scores between individuals who did and did not achieve SVR did not reach statistical significance. 29 In another study, there were no improvements in SVR despite pharmacologically induced improvement of IR with metformin. 30 Some studies have shown a statistically significant decrease in HOMA-IR scores with viral eradication and achievement of SVR. 28 , 31 When using precise measurements, IR did not appear to be substantially associated with achievement of SVR.

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