Lack of salt-inducible kinase 2 (SIK2) prevents the development of cardiac hypertrophy in response to chronic high-salt intake.

Transient overexpression of the hypertensive α-adducin did not change the SIK2 mRNA expression ( Figure 4B ), but it did result in an increase (a trend that did not reach statistical significance) in SIK2 catalytic activity ( Figure 4C ) when compared to cells transiently overexpressing the normotensive variant.

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