The correlation between MIS/SYN and the total intron length was negative but did not reach statistical significance (R = −0.03, n = 3,363, P = 0.11), whereas the correlation between NON/SYN and the total intron length was significant (R = −0.13, n = 3,363, P < 10 −6 ).
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Genes with a large intronic burden show greater evolutionary conservation on the protein level.
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