GFAP mRNA expression in lumbar spinal cord on day 22 (i.e., approximately 24 h after the pump ceased to release drug) showed a trend toward increased expression in paclitaxel- relative to cremophor-treated controls, while no change in CD11b expression was observed.
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Prophylactic cannabinoid administration blocks the development of paclitaxel-induced neuropathic nociception during analgesic treatment and following cessation of drug delivery.
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