Loss of function of endothelin-2 leads to reduced ovulation and CL formation.

The difference in oocytes ovulated in Edn2KO mice did not reach statistical significance ( Table 4 , p = 0.128), likely due to a small sample size and high variation in oocyte number in normal ovulation, though all EDN2-injected ovaries ovulated an increased number of oocytes relative to their contralateral PBS-injected counterparts.

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