Red-clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial [ISRCTN42940165].

Correlations between estimated percentage densities assigned by both radiologists were highly significant for the baseline and 12-month mammograms ( r = 0.79, P < 0.01 and r = 0.85, P < 0.01, respectively).

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More recently, data from a cross-sectional study of soy food intakes and mammographic densities [ 26 ] indicated the presence of a significant trend toward higher percentage density through increasing quartiles of soy intake, but a small study of a soy isoflavone supplement [ 27 ] did not significantly alter breast density after 1 year of treatment.

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