Targeting TGF-β Signaling by Antisense Oligonucleotide-mediated Knockdown of TGF-β Type I Receptor.

Mol Ther Nucleic Acids · 2014 · PMC4011125 · PMID 24691207

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a slight trendno p-value reported

19 , 35 Although we did observe an effect on gene expression and Serpine1/pSmad2 protein levels, no significant effect on the percentage of fibrotic/necrotic areas was observed compared to control-injected muscles and only a slight trend of increased fiber size was shown.

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showed a trendno p-value reported

Western blot analysis also showed a trend of decreased levels of phosphorylated Smad2 upon intramuscular injection with ALK5 AONs, although this was not significant due to the considerable variation between different samples ( Figure 5c , d ).

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