A separate observational cohort study examined the role of bevacizumab after disease progression in patients who did or did not received first-line bevacizumab and showed a trend towards longer OS in patients who had first- and second-line bevacizumab exposure (median OS, 21.7 months) than in patients who only received bevacizumab after progression (median OS, 17.5 months) [8] .
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Efficacy and safety of bevacizumab plus chemotherapy in Chinese patients with metastatic colorectal cancer: a randomized phase III ARTIST trial.
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