microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers.

The four miRNA signature subclassification performed better in discriminating high risk patients in comparison to the IHC subtyping (HR=6.19; 95% CI = 2.45-32.16; p=0.001).If the group of patients for whom chemotherapy treatment information was not available (NA) are stratified according to IHC status there is a clear trend toward worse survival of the CB subtype (Supplementary Figure 2A ); also the four miRNA predictor can even more clearly separate this cohort into high/low risk cancers (HR=4.07; 95% CI = 1.44-9.75; p=0.007) (Supplementary Figure 2B ).

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